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Chlortalidone or chlorthalidone is a diuretic medication used to treat hypertension , originally marketed as Hygroton in the USA. It is described as a thiazide diuretic . Compared with other medications of the thiazide class, chlortalidone has the longest duration of action but a similar diuretic effect at maximal therapeutic doses. It is often used in the management of hypertension and swelling due to fluid retention .