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Diffusion is the net movement of molecules or atoms from a region of high concentration to a region of low concentration . This is also referred to as the movement of a substance down a concentration gradient. A gradient is the change in the value of a quantity with the change in another variable . For example, a change in concentration over a distance is called a concentration gradient, a change in pressure over a distance is called a pressure gradient, and a change in temperature over a distance is a called a temperature gradient.