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Dysphoria , ???-, difficult, and ??????, to bear) is a profound state of unease or dissatisfaction. In a psychiatric context, dysphoria may accompany depression, anxiety, or agitation. The term is often used to refer to gender dysphoria, experienced by people whose gender identity does not align with their sex assigned at birth, and who may undergo sex reassignment surgery. Common reactions to dysphoria include emotional distress; in some cases, even physical distress. The opposite state of mind is known as euphoria.