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Hydroxychloroquine , sold under the trade names Plaquenil among others, is an antimalarial medication. It is also used to reduce inflammation in the treatment of rheumatoid arthritis and lupus. Hydroxychloroquine differs from chloroquine by the presence of a hydroxyl group at the end of the side chain: the N-ethyl substituent is beta-hydroxylated. It is available for administration by mouth as hydroxychloroquine sulfate.