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Hypersensitivity is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. They are usually referred to as an over- reaction of the immune system and these reactions may be damaging, uncomfortable, or occasionally fatal. Hypersensitivity reactions require a pre-sensitized state of the host. They are classified in four groups after the proposal of P. G. H. Gell and Robin Coombs in 1963.