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Ayahuasca[note 1] is a South American entheogenic brew commonly made out of the Banisteriopsis caapi vine, the Psychotria viridis shrub or a substitute, and possibly other ingredients;[1] although, in the West, a chemically similar preparation also known and sold as ayahuasca, but occasionally also known as "pharmahuasca", can be prepared using illicitly manufactured N,N-dimethyltryptamine and a pharmaceutical monoamine oxidase inhibitor such as isocarboxazid.[2][3] The brew is used as a traditional spiritual medicine in ceremonies among the indigenous peoples of the Amazon basin.[4]