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An atheroma is an accumulation of degenerative material in the tunica intima of artery walls. The material consists of macrophage cells, or debris, containing lipids , calcium and a variable amount of fibrous connective tissue. The accumulated material forms a swelling in the artery wall, which may intrude into the channel of the artery, narrowing it and restricting blood flow. Atheroma occurs in atherosclerosis, which is one of the three subtypes of arteriosclerosis .